Nifedipine for High Blood Pressure
Nifediine is a calcium slow-channel blocker and an antianginal drugthat selectively inhibits the influx of calcium ions into both cardiacmuscle. In addition it dilates arteries and arterioles of the heart andinhibits coronary spasms, which improves oxygen delivery. In addition ithas a mild effect on systolic and diastolic blood pressure readings.Usually this change is small, i the range of 5 - 10 hg,
It treatschronic angina when beta-blockers or nitrates have failed or in patientswho do not tolerate those medications well. In addition there is some clinical evidence that nifedipine orProcardia may reduce platelet aggregation. but sometimes thedifference is more robust. No specific warnings are givenregarding dental care, although it should be noted that nifedipine has amoderate anticoagulant effect. There are several warnings regarding nifedipine. Documented incidents ofsevere hypotension followed by myocardial infarction and death fromnifedipine have been noted, and it should not be used to achieve bloodpressure reduction. Some patientsexperience marked drops in low blood pressure, sometimes but not alwayswhen used in combination with a beta-blocker. There are no well-done studies demonstrating safety orefficacy for nifedipine when used this way and its use for control ofessential hypertension is contra-indicated. Nifepidine treats vasoplastic angina when that angina has beenconfirmed either by documentation of classical angina pattern; provocationof angina with ergonovine, or as confirmed on an angiogram. Close monitoring is requiredwhen a patient taking nifedipine or Procardia also is taking medication tolower blood pressure.
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