Von Willebrand Disease
Von Willebrand disease is a condition the effects approximately 1% of the general population (Lipkind et al, 2005). In years past, there has been a great deal of research conducted related to the treatment of the disease. The purpose of this discussion is to explain what the condition is, what causes it and how it can be prevented. The research will also investigate the risk factors associated with the disease and treatment options. What causes the condition and how can it be prevented? According to the Indian journal of Medical Research Von Willebrand disease (VWD) is a bleeding disorder that is an inherited ailment (Sucheta et al, 2005). The disease can also be acquired in some rare cases (Lipkind et al, 2005) The journal explains that this disease occurs as a result of a quantitative or qualitative deficie
The article explains that there are three different types of VWD. Those that suffer from von Willebrands disease usually suffer from excessive bleeding following surgical or dental procedures (Perry & Alving, 1990). This process prevents the attachment of fibrin and the development of plasminogen that is unavailable within the forming clot. ncy associated with the von Willebrand factor (VWF) (Sucheta et al, 2005). If either of these factors is abnormal a physician will determine whether or not to test for the disease. There are different forms of the disease that are determined by the different patterns of genetic transmission and defects of VWF found in plasma and platelets (Sucheta et al, 2005). The treatment of VWD can be administered using nontransfusional therapis such as Desmopressin. The 1st type is associated with a limited absence of VWF. Antifibrinolytic amino acids are useful in the treatment of this disease because they impede the lysis of newly developed clots by inundating and then binding sites on plasminogen (Mannucci, 2001). When administered to healthy volunteers or patients with mild hemophilia and vWD,4 desmopressin increases VIII and vWF transiently by releasing these moieties from storage sites into plasma (Mannucci, 2001). However patient responses to such preparations are so unreliable that they are not normally used for most people with the disease (Mannucci, 2001). The 2nd type is associated with a qualitative defect in the VWF. The diagnosis of the condition can be determined through an evaluation of the patients bleeding and family history. An article found in the journal American Family Physician explains that Von Willebrands disease is the most common of all inherited bleeding disorders.
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