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Cancer in siblings of children with cancer in the Nordic co

The Lancet

Vol. 358; pages 711-717, September 1, 2001

Cancer in siblings of children with cancer in the Nordic countries:
A population-based cohort study

Jeanette Falck Winther, Risto Sankila, John D Boice Jr, Hrafn Tulinius, Andrea
Bautz, Lotti Barlow, Eystein Glattre, Froydis Langmark, Torgil R Moller, John
Mulvihill, Gudridur H Olafsdottir, Annukka Ritvanen, Jorgen H Olsenet


Introduction

Relevance: In some inherited childhood cancers there is an increased risk

of children and their siblings getting cancer.

Hypothesis: By studying the relationship between children with cancer and

genetic heredity and by evaluating the influence of recessive cancer causing

conditions, the study hoped to determine that children whose siblings have

common types of cancer are not at an increased risk of getting cancer themselves


Experimental Design

Forty two thousand two hundred and seventy-seven siblings, from 5

Scandinavian countries (Denmark, Finland, Iceland, Norway and Sweden) of

25,605 children with cancer were selected by accessing linkage records and cancer

registries of surviving children and adolescents with cancer. Fourteen thousand

childhood cancer survivors were compared with the expected number of cancers

among children in the general population. Excluded from the study were 56

families with cancer linked genes, adopted and half-siblings. The index patient in

the family was the child with the earliest diagnosis date of cancer. The siblings

were all younger than 20 years old from 1943 in Denmark, 1953 in Finland and

Norway, 1954 in Iceland, and 1958 in Sweden.


They analyzed the relationships between specific childhood cancers and the risks

of cancer in a family from a large population for 40 years. Follow up ended at the time of

death or if the subject emigrated, or December 31, 1994, which ever came first (except

for Norway which ended i...

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