Cancer in siblings of children with cancer in the Nordic co
Vol. 358; pages 711-717, September 1, 2001Cancer in siblings of children with cancer in the Nordic countries: Jeanette Falck Winther, Risto Sankila, John D Boice Jr, Hrafn Tulinius, Andrea Bautz, Lotti Barlow, Eystein Glattre, Froydis Langmark, Torgil R Moller, John Mulvihill, Gudridur H Olafsdottir, Annukka Ritvanen, Jorgen H Olsenet Relevance: In some inherited childhood cancers there is an increased riskof children and their siblings getting cancer. Hypothesis: By studying the relationship between children with cancer and genetic heredity and by evaluating the influence of recessive cancer causing conditions, the study hoped to determine that children whose siblings have common types of cancer are not at an increased risk of getting cancer themselvesForty two thousand two hundred and seventy-seven siblings, from 5 Scandinavian countries (Denmark, Finland, Iceland, Norway and Sweden) of 25,605 children with cancer were selected by accessing linkage records and cancer registries of surviving children and adolescents with cancer. Fourteen thousand childhood cancer survivors were compare
Results There is no evidence of a significantly increased risk of nonhereditary cancer among survivors of children with cancer or evidence that recessive conditions might contribute to genetic cancers. develops cancer prior to the age of nineteen. When hereditary cancers are excluded from the study, children are not at risk getting family related cancers. The siblings were all younger than 20 years old from 1943 in Denmark, 1953 in Finland and Norway, 1954 in Iceland, and 1958 in Sweden. Follow up ended at the time of death or if the subject emigrated, or December 31, 1994, which ever came first (except for Norway which ended in 1987). (MEDLINE July 1996; 74(1): 152-8) "Childhood cancers have increased by 26% overall, while the incidence of particular cancers has increased still more". Specific childhood cancers, brothers and sisters, age of the children at diagnosis, sex and year of birth of each of the Nordic countries were indexed and studied. When 56 families with genetic syndromes linked to cancer were excluded from this study, the risk of cancer in siblings younger than 20 years old up to 29 years of age were dramatically reduced. Cancer siblings of the main diagnostic group were broken down into 11 specific childhood cancers. Excluded from the study were 56 families with cancer linked genes, adopted and half-siblings. d with the expected number of cancers among children in the general population. The index patient in the family was the child with the earliest diagnosis date of cancer. With the exception of genetic cancers, what causes most childhood cancers are unknown. This study substantiated its findings that it is unlikely there are any undiscovered genes that may cause childhood cancer. (PRNewswire CHICAGO, May 9, 2003) One in every 330 children in the U.
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