Cancer in siblings of children with cancer in the Nordic co

Cancer in siblings of children with cancer in the Nordic countries:

Jeanette Falck Winther, Risto Sankila, John D Boice Jr, Hrafn Tulinius, Andrea

Bautz, Lotti Barlow, Eystein Glattre, Froydis Langmark, Torgil R Moller, John

Mulvihill, Gudridur H Olafsdottir, Annukka Ritvanen, Jorgen H Olsenet

Relevance: In some inherited childhood cancers there is an increased risk

of children and their siblings getting cancer.

Hypothesis: By studying the relationship between children with cancer and

genetic heredity and by evaluating the influence of recessive cancer causing

conditions, the study hoped to determine that children whose siblings have

common types of cancer are not at an increased risk of getting cancer themselves

Forty two thousand two hundred and seventy-seven siblings, from 5

Scandinavian countries (Denmark, Finland, Iceland, Norway and Sweden) of

25,605 children with cancer were selected by accessing linkage records and cancer

registries of surviving children and adolescents with cancer. Fourteen thousand

childhood cancer survivors were compare

. . .

Results

There is no evidence of a significantly increased risk of nonhereditary cancer

among survivors of children with cancer or evidence that recessive conditions

might contribute to genetic cancers. develops cancer

prior to the age of nineteen. When hereditary cancers are excluded from the study, children

are not at risk getting family related cancers. The siblings

were all younger than 20 years old from 1943 in Denmark, 1953 in Finland and

Norway, 1954 in Iceland, and 1958 in Sweden. Follow up ended at the time of

death or if the subject emigrated, or December 31, 1994, which ever came first (except

for Norway which ended in 1987). (MEDLINE

July 1996; 74(1): 152-8) “Childhood cancers have increased by 26% overall, while

the incidence of particular cancers has increased still more”. Specific childhood cancers,

brothers and sisters, age of the children at diagnosis, sex and year of birth of each of the

Nordic countries were indexed and studied. When

56 families with genetic syndromes linked to cancer were excluded from this study,

the risk of cancer in siblings younger than 20 years old up to 29 years of age were

dramatically reduced. Cancer siblings of the main diagnostic group were

broken down into 11 specific childhood cancers. Excluded from the study were 56

families with cancer linked genes, adopted and half-siblings. d with the expected number of cancers

among children in the general population. The index patient in

the family was the child with the earliest diagnosis date of cancer. With the exception of genetic cancers, what causes most

childhood cancers are unknown. This study substantiated its findings that it is

unlikely there are any undiscovered genes that may cause childhood cancer. (PRNewswire

CHICAGO, May 9, 2003) One in every 330 children in the U.

Common topics in this essay:
Finland Norway, PRNewswire CHICAGO, Norway Sweden, Introduction Relevance, Lancet Vol, MEDLINE July, Design Forty, childhood cancers, children cancer, cancer siblings, increased risk, cancer survivors, getting cancer, specific childhood, risk getting, excluded study, siblings children cancer, childhood cancer, specific childhood cancers, childhood cancer survivors, cancer siblings 20, cancer survivors children,

Approximate Word count = 910
Approximate Pages = 4 (250 words per page double spaced)

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