Cancer in siblings of children with cancer in the Nordic co

             Vol. 358; pages 711-717, September 1, 2001
             Cancer in siblings of children with cancer in the Nordic countries:
             Jeanette Falck Winther, Risto Sankila, John D Boice Jr, Hrafn Tulinius, Andrea
             Bautz, Lotti Barlow, Eystein Glattre, Froydis Langmark, Torgil R Moller, John
             Mulvihill, Gudridur H Olafsdottir, Annukka Ritvanen, Jorgen H Olsenet
             Relevance: In some inherited childhood cancers there is an increased risk
             of children and their siblings getting cancer.
             Hypothesis: By studying the relationship between children with cancer and
             genetic heredity and by evaluating the influence of recessive cancer causing
             conditions, the study hoped to determine that children whose siblings have
             common types of cancer are not at an increased risk of getting cancer themselves
             Forty two thousand two hundred and seventy-seven siblings, from 5
             Scandinavian countries (Denmark, Finland, Iceland, Norway and Sweden) of
             25,605 children with cancer were selected by accessing linkage records and cancer
             registries of surviving children and adolescents with cancer. Fourteen thousand
             childhood cancer survivors were compared with the expected number of cancers
             among children in the general population. Excluded from the study were 56
             families with cancer linked genes, adopted and half-siblings. The index patient in
             the family was the child with the earliest diagnosis date of cancer. The siblings
             were all younger than 20 years old from 1943 in Denmark, 1953 in Finland and
             Norway, 1954 in Iceland, and 1958 in Sweden.
             They analyzed the relationships between specific childhood cancers and the risks
             of cancer in a family from a large population for 40 years. Follow up ended at the time of
             death or if the subject emigrated, or December 31, 1994, which ever came first (except

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