Tay-Sachs Tay-Sachs disease is a genetic disorder that occurs in children. This disease causes their central nervous system to breakdown, which in turn is the basis for their death. The disease is named for Warren Tay and Bernard Sachs. Tay-Sachs disease is caused by the absence of an enzyme called Hexosamindase A, which is referred to as Hex-A. The lack of this enzyme causes many metabolic problems for its host because it is necessary for breaking down wastes within the brain. The result of its absence is that it causes an increasing loss of coordination, a progressive inability to swallow, breathing difficulties, blindness, mentally retardation, paralysis, and finally death. The enzyme known as Hex-A is extremely essential for a person to sustain life. This is due to the fact that Hex-A is needed for the body to break down a fatty waste substance found in brain cells. This fatty substance or lipid called GM2 gangliosi
There are two copies of chromosome number 15 in all the body cells and therefore two copies of the gene that codes for the enzyme necessary for correct brain function. As soon as they find out their child is afflicted they must face the inevitable fact that he will die in 5 short years. The inheritance pattern of Tay-Sachs disease is autosomal recessive. Many metabolic disorders plague people throughout the world, yet few are as terrible and devastating to a family as Tay-Sachs disease. Tay-Sachs is an autosomal recessive trait, meaning it is manifested in an individual through hereditary. Bibliography1. The information for the body to make the Hex A enzyme is contained in a gene which is found on chromosome number 15. In order for a child to inherit a recessive condition such as Tay-Sachs they must receive a recessive gene from both their father and mother. Bone marrow transplantation has also been attempted, but to date has not been successful in reversing or slowing damage to the central nervous system in babies. As wastes are constantly collected, there is a progressive damage to the cells. By the that time a child with the disease is three or four years old and the nervous system is so badly affected that life itself cannot be supported.
Some topics in this essay:
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