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germ line gene therapy

Whether it is referred to by its scientific term "syngamy" or by the general term "conception", the moment a sperm cell unites with an egg cell stirs, both in the scientist and the layperson, much awe and reverence. It is the point at which a new and unique genome is created. To some it is the instant a new person comes into existence. Such a union has been repeated for billions of years since its advent in the first, simple organisms. It is a means by which evolution can exert its influence. When the genetic material of two individuals combine in sexual reproduction, any variations between the two inherited sets of genes may result in offspring that are more or less suited to its environment. Human beings have come to a point in this process where we can now, to an extent, shape the environment to suit our needs. The evolution of intelligence in our specie is the characteristic that has had the most profound impact on our planet and on us. This intelligence, among other things, allows us to understand and combat some genetic diseases. Inventions such as spectacles to correct our vision or drugs that fight heart disease and cancer have extended and improved the lives of individuals who, in a more Darwinian world, w


Many questions have come to light in regards to the ethics of such technology. Will society ever encounter issues like eugenics or the manipulation of evolution because of germ-line therapy? Such questions may not be answered for years. Although researchers may find ways to keep germ-line alterations form being passed on to future generations, eugenics would be an ever-present concern to society. ould have otherwise been eliminated by natural selection. Gray closes, " [The eugenicists] were wrong, with unintended consequences for millions of people. Biophysicist Gregory Stock of UCLA sums up the most profound implication of this research. Such manipulation will most likely come in the form of gene therapy. Currently, according to the article, the National Institutes of Health "refuses to even consider funding proposals" for germ-line research. But careful public deliberation should allay fears and allow us to develop an ethical framework that will guide society and the scientific community in any decision making process. This dramatic change in life expectancy, however, has not been a result of medical advances. As a result, researchers have looked for new tools in the fight against genetic diseases. Thus far, conventional techniques of gene therapy have not been beneficial. Though not likely to occur, such viewpoints can be appreciated for the guidance they may one day provide. What is certain and what is real is that the benefits of such research hold the promise of improved health for many people.

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