hemophilia
Hemophilia is a genetic bleeding disorder. People who have hemophilia have a deficiency or an absence of a coagulation protein. A blood clotting factor is deficient or absent. Bleeding is most often into joints, such as the knee, elbow, or ankle, but bleeding can occur anywhere in the body. People with hemophilia bleed longer, not faster. The severity of hemophilia varies greatly. Hemophilia A and Hemophilia B are the most common genetic bleeding disorders. Hemophilia A is observed in 80 percent of hemophiliacs and is a deficiency or absence of Factor VIII. It can also be referred to as "classic" hemophilia. In the second most common, hemophilia B, factor IX is missing. This is also known as the "Christmas Disease" because of the surname of the first patient studied. Hemophilia was identified as early as biblical times. Doctors in medieval times were familiar with it as well. In 1803, a Philadelphia doctor published the first description of hemophilia in the United States. But it was not until 30 years later that hemophilia became widely recognized. Hemophilia later developed a reputation as the "royal disease" because it passed from Queen Victoria of England to her descendants throughout the royal houses of Europe.
The first part has to do with platelets. The most significant advances in hemophilia treatment have been made in the last four decades. There are two important points to keep in mind: A fresh bleeding episode can start if the clot becomes dislodged and natural reactions in the body cause a clot that is no longer needed to "break down" or to be dissolved. These antibodies will inhibit the ability of the factor to work in the clotting process. The plug is only temporary, and the platelets can easily fall off. In persons with hemophilia A, fibrin is not made properly, so firm blood clots do not form in the wound, and bleeding continues. com c 1997-2000 Microsoft Corporation. are tested for blood borne viruses and all blood products are tested for hepatitis and the virus that causes AIDS. Sling, splints or crutches may be necessary for support for several days. "Hemophilia," Microsoftc Encartac Online Encyclopedia 2000http://encarta. Attempts to move the joint forcibly can cause pain. When the body detects bleeding, clotting factors are switched on in a specific order, each sending an activating message to the next. The processes begin approximately five days after the initial clot was formed and occasionally a bleed may restart at the site. Later the person holds the limb in a bent or "flexed" position to ease pain.
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