The Brief Description of the Role of Intercellular Adhesion Molecules in
This paper reports studies and findings of the intercellular adhesion molecule in relationship to the common cold virus and rheumatic diseases. The role of the cell and intercellular adhesion molecules is also examined. Cell-cell adhesion is required at all stages of development and is of importance in the establishment and maintenance of the organized structure and function of multicellular organisms. The cell is the basic unit that all living things are composed of. As an individual unit the cell is capable of digesting its own nutrients, providing its own energy, and replicating itself in order to produce future generations. Cooperative groups of similar cells form tissues, and a cooperation between tissues in turn, forms organs, the functional units of an organism (Hunter et al.,1996). Intercellular adhesion brings cells together to help perform special needs (Encyclopedia Britannica). The simplest examples of the ability of cells to recognize and adhere to one another come from organisms that live much of their lives as single cells but form a multicellular aggregate, or gather, for a specific purpose (Hunter and others 1996). For example, when starved, several types of single-cell organisms band together to develop
Modern molecular biology has enabled one to obtain considerable structural information and sequence data on these molecules, revealing simi!larities between molecules from diverse cell types. Cell-cell adhesion is required at all stages of development and is of fundamental importance in the establishment and maintenance of the organized structure and function of multicellular organisms (Hunter et al. The ability of cells to adhere to each other and components of the extracellular matrix (ECM) is a fundamental property of all multicellular organisms (Clayton et al. It is currently considered that the main role of selectins is to mediate the initial contact between flowing leukocytes and endothelial cells(Roebuck and Finnegan 1999). Adhesion molecules play a role in binding cells to other molecules or cells. According to Hunter and colleagues it was stated that within a given tissue, CAM's appear to be expressed in a characteristic spatiotemporal(pertaining to both space and time) sequence and alterations in the normal distribution of CAM's are often associated with changes in cell morphology. Clayton A, Evans R, Pettit E, Hallett M, Williams J, and Steadman R. Roebuck and Finnegan's results were consistent and demonstrated a new property of endothelial selectins(adhesions among cells of a different type). The cellular aggregates then produce an extracellular matrix!, which holds the cells together in a specific form (Hunter et al. Besides increasing the understanding of cellular interactions involved in inflammation, studies on these molecules have prompted the search for new anti-inflammatory agents which may interfere with adhesion mediated events in the inflammatory process.
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