Modeling of Water Uptake
Modeling of Water Uptake into Polymeric Aerosol Particulates Deposited on the Lung SurfaceInhalation of aerosolized drugs holds promise as a means to treat localized disease states within the lung and may also represent an ideal method for drug delivery to the systemic circulation. The use of polymer-based aerosol carriers for controlled drug delivery via the lung is an approach that may improve the duration and effectiveness of drugs delivered to the respiratory tract. However, the ability to optimize new formulations for pulmonary drug delivery has been limited by the inability to closely mimic the conditions the particles encounter in the various regions of the lung.Conventional "complete immersion" methods used to characterize microparticle water uptake rates, polymer degradation kinetics, and drug diffusion rates may not be relevant for particles designed for inhalation due to the extremely thin aqueous layers in the lungs. In this paper, I discuss the forces on a particle at the air-surfactant-particle interface used to determine the extent of submersion. Then, I model the water uptake into particles completely immer
Therefore, the more hydrophilic the particle, the greater the particle submersion. 1 g/cc) polymer-based aerosol carriers for controlled drug delivery via the lung. 26 g/ml) caused less particle submersion than a surface tension of 30 dyn/cm. However, the ability to optimize new formulations for pulmonary drug delivery has been limited by the inadequate models used to mimic the conditions the particles encounter in the various regions of the lung.
Common topics in this essay:
Introduction Inhalation,
Using Langmuir-Wilhelmy,
Calculations Force,
Abstract Inhalation,
surface tension,
water uptake,
drug delivery,
aqueous layers,
surfactant film,
line tension,
particles submersed,
larger particles,
particles diameter,
respiratory tract,
Transport December,
improve duration effectiveness,
water uptake spherical,
water uptake particles,
particles partially submersed,
uptake spherical particles,
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Acceptance Essays
