Thomas Gradgrind`s family is ruled by fact, and the school is in Coketown, a northern industrial town over which he presides is also dominated by it. He is displeased by Sissy Jupe, a circus clown`s daughter, because of her unrealistic upbringing: and appalled when he finds his own children, Louis...

Myasthenia Gravis (MG) is a chronic autoimmune disorder of neuromuscular transmission resulting in muscle weakness. The term "myasthenia" is latin for muscle weakness, and "gravis" for grave or serious. Myasthenia gravis is characterized by decremental neuronal response with repe...