rventions against different levels in the cycle of transmission. Interventions designed to prevent transmission are at the primary level, and this is concerned with controlling the disease. At the secondary level are interventions designed to prevent/inhibit disease in cases where infection has occurred and this is what treatment of the Chagas' involves [4] & [5].
In this essay I shall discuss control strategies of Chagas' including how the modern era of control has developed. I shall then discuss treatment of Chagas' and the future drugs being considered.
Control is a means designed to prevent transmission. The more you can understand how the disease is transmitted, the more efficiently you can control it. So before discussing control strategies, modes of transmission will be shown by Table 0:
Mode of Transmission Example % of Transmission it Accounts For: Relative importance:
Transfusional transmission From blood donor to blood recipient 15% 2
Congenital transmission Via a placenta from infected mother to unborn child 4% 3
Via an organ transplant Kidney <1% 4
Accidental transmission Spilling a contaminated culture <1% 5=
Social behaviours Kissing the bugs as 'aphrodisiacs' <1% 5=
The development of control techniques against the vector:
At the start of 1940's, Emmanuel Dias - one of Chagas' disciples - was involved in the first efforts of systematic control of the disease. Dias understood that the transmission of T.cruzi was dependant on an infected vector in human dwellings; in his early attempts at killing the vector Tryatoma infestans, Dias tried everything to remove them from human dwellings including even limited attempts of using military flamethrowers! However at the time, the best results were acquired using a mixture of rotenone and kerosene, which had a huge impact on T. infestans populations, and then improving the conditions of the
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