)
             CD4+CD25+ have been shown not to proliferate in the absence of exogenous IL-2, don't secrete known cytokines, require cell to cell contact (this is controversial apparently only one paper on this phenomenen), inhibit IL-2 transcription in the responsive T cells and appear to be antigen non specific in their effector function(77)
             Immunosuppressive properties of IL-10 and TGF-b are most likely explained by the ability of these cytokines to inhibit APC function (85-88) and to mediate direct anti proliferative effects on T cells. (89-91)
             Cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression is primarily restricted to CD4+CD25+ T cells (23,28,29) suggesting that it may be important in regards to suppressor function. The precise function of CTLA-4 remains t
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