he second stage deals with resistance as the body prepares for possible long-term endurance of the affecting stressor. During this stage, the body experiences the second neurophysiological reaction known as the Pituitary Adrenal Response. Occurring approximately ten seconds after the Sympathetic Adrenal Response, the hypothalamus secretes a corticotropic hormone (CRF) stimulating the pituitary gland. Upon stimulation, the pituitary gland secretes an adrenocorticotropic hormone (ACTH) and beta-endorphins, which influence our ability to make adaptive responses, contributes to feelings of euphoria, and stimulates the adrenal cortex. The adrenal cortex, in turn, releases glucocorticoids (co
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