, usually depression, or loss of interest or pleasure in most usual activities and pass-times. This disturbance is prominent, relatively persistent, and associated with other symptoms of the depressive syndrome." These symptoms include appetite disturbance, change in weight, sleep disturbance, psychomotor agitation or retardation, decreased energy, feelings of worthlessness or guilt, difficulty concentrating or thinking, and thoughts of death or suicide, or suicidal attempts.
             Manic Depression is also due to a biochemical imbalance in the brain. These biochemical reactions include the "increasing and decreasing of intra- and extracellular sodium, chloride, and potassium (Beck 65)." The inclining and declining of these functions support the contrasting manic and depressive moods. "The spirit of genius no free-floating, absolute power, but is strictly bound to the laws of biochemistry and the endocrine glands." This aga
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