is why it is commonly called APC Resistance.
             Factor V Leiden is the most common genetic cause of venous thrombosis, which leads to deadly pulmonary embolism when the part of the clot breaks away to the pulmonary artery. It is involved in 20-40% of cases and is present in 3% of the general population.
             The other major genetic causes of venous thrombosis (deficiencies of protein C and S) together account for only 5-10% of cases.
             Factor V Leiden increases the risk of venous thrombosis 3-8 times for heterozygous (one bad gene inherited) and substantially more, 30-140 times for homozygous (two bad gene inherited) individuals.
             2% of the general population was found to be heterozygous.
             Risk is increased still further in situations such as pregnancy, oral contraceptive use, estrogen therapy, malignancy, diabetes mellitus, immobilization, surgery, trauma, high blood pressure, obesity, smoking or long time travel (commonly called economy class syndrome). In these cases risk of clotting can increase dramatically.
             Genetic mutations are passed from gener
             ...