immunology grant proposal

f four months gestation, thus
             they are capable of producing antibodies along with the ones that they receive via the placenta in
             passive immunity. We also know that there are antibodies specific for toxoplasmosis. Lastly, we
             know that the disease is treatable, only after infection is acquired, by which time irreversible damage
             Toxoplasmosis is the common name given to the disease caused by the protozoan
             Toxoplasmosa gondii. The disease is usually found in animals, and has found to be transmitted to
             pregnant mothers by poor handling of cats (which are the only carriers of the protist's oocysts or
             eggs), and by ingesting uncooked meat. The protists enter the body in the form of trophoziotes,
             which can reside in tissues in the form of tissue cysts. It is this form that can possibly reside in the
             placenta, and thus release its contents into the blood and then cross the barrier to the fetus.
             We still need to know why the disease is so devastating to the fetus. We need to know if a
             healthy, pregnant mother's antibodies to toxoplasmosis can cross the placenta to the unborn fetus, or
             if the placenta blocks them by some mechanism. We also need to know if the fetus produces
             antibodies specific for toxoplasmosis. To answer these questions, a series of experiments have to be
             devised. Such experiments must be carried out in vivo most of the time. This would call for subjects
             who would be willing to give to experimental conditions. These conditions would include placental
             tissue samplings, and blood samplings as well. Some experiments can be conducted in vitro. These
             would be various assays needed to test the blood for presence of antibodies, antigen, etc.
             The first experiment to carry out would involve pregnant
             ...

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