tlawed cocaine in 1914 is that is a very addictive drug. This a due to the permanent molecular adaptations of the neurons involved in the cocaine's effect so that they can no longer transmit normally across synapses without increasingly higher doses of the drug. Over time the postsynaptic cells that are stimulated permanently expect a high level of stimulation and then they are addicted to the drug. Then when the cocaine molecules diffuse away the sense of pleasure that cocaine gives evaporates because the normal level of dopamine no longer satisfies the overly needy demands of the postsynaptic c
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