r (90-kd protein), to form lethal toxin.
             Anthrax lethal factor is the active component of the protein exotoxin, the lethal toxin, secreted by toxigenic strains of B. anthracis. Lethal toxin is an A-B type toxin consisting of two non-covalently bound factors, the lethal factor and the protective antigen. The protective antigen binds to a ubiquitous receptor on the plasma membrane and is processed proteolytically by membrane peptidases, including furin, to a 63kDa form that is able to oligomerize and bind the lethal factor. Upon endocytic uptake, the protective antigen undergoes an ac
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