Central Dogma

erforms T (DNA polymerase catalyzes DNA rep). RP catalyzes formation of phosphodiester bonds linking n'tides together, RP moves along DNA, unwinding DNA double helix just ahead of active site for polymerization to expose a new region of template strand for complementary base pairing. Therefore the growing RNA chain is extended one nucleotide at a time in 5'-3' direction. Substrates include ATP, CTP, UTP, GTP (as in DNA rep), hydrolysis of high energy bonds provide energy to drive reaction forward.
             Many copies of RNA can be made from same gene in short time since synthesis of more RNA molecules start before first RNA is completed., Each RP moves ~20N/s, over a 100 transcripts can be yielded in an hour to give 1 gene.
             1. RP catalyzes linking of ribonucleotide not deoxyribo.
             2. RP can start RNA chain without primer unlike DP since T in DNA rep requires more precision.
             However, RP is still decent at its proofreading mechanism, If incorrect R, tide added to RNA chain, RP backs out and its active site performs an excision reaction mimicking reverse of polymerization reaction, RP also favors excision for incorrect nucleotide by moving for a mistake longer. Also excises many correct bases for improved accuracy.
             mRN@ Specifies aa sequence of a protein. Produced by RNA splicing from a larger RNA molecule made by RNA poly as a complementary copy of DNA. It is translated into P via process catalyzed by ribosome. These RNA serve a variety of processes in cell.
             snRN@ Direct splicing of pre-Mrna TO GIVE Mrna.
             tRN@ Forms adaptors selecting aa and holds them in place on a ribosome for incorporation into Protein.
             Most RNA in cells is rRNA, mRNA only being 3-5% of total RNA.
             In Eukaryotes, T unit carries info of just one gene and codes for either single RNA molecule or single protein ( or related proteins of transcript spliced more than once to give different mRNA). In bacteria, resulting mRNA CARRIES INFO FOR SEVE...

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